电影《家庭主妇否定式》基于大热舞台剧《家庭主妇的独白》改编。两姐妹和她们的母亲原本拥有很大分歧，但是因对家、对生活的反思，暂时搁置。 Gijsje是一位年轻、野心勃勃的控制狂。她非常渴望怀孕，也非常希望在广告公司获得晋升。她的姐姐Marjolein已经结婚，是三个孩子的妈妈，她刚丢了份记者的工作。不过她有了新的抱负，当一名接送孩子上下课的妈妈。她们波西米亚的母亲Loes在她漂亮的房子上借了不少贷款，给自己带来了麻烦。两姐妹不想失去他们的家庭，开始寻找拯救的方法。只有靠Gijsje想广告的金点子才能缓解他们的财政危机。这意味着她要与她迷人的同事Dominique探讨“现代家庭主妇”这个概念。这个任务比很多人想的要复杂的多。Two sisters and their mother are forced to set aside their differences as they reflect on the lives they are living and the homes they are running.Gijsje is a young, ambitious control freak who is desperate to get pregnant and climb the ladder at the advertising agency where she works. Her older sister Marjolein is married with three kids and has just lost her job as a journalist. Her new ambition: to become a school run mum.Their bohemian mother Loes has got herself into trouble by taking out too many mortgages on her beautiful home. Gijsje and Marjolein cannot bear to lose their family home and start looking for a way to save it. Only the bonus that Gijsje can earn by coming up with the golden idea for an advertising campaign can get them out of financial trouble. This means working with her attractive colleague Dominique to explore the concept of the "modern day housewife"; a task that dredges up a lot more than the women ever bargained for."No such thing as a housewife" is based on the popular theatre performance "The Housewife Monologues".

施耐德（汤姆·德·威斯布莱尔 Tom De Wispelaere 饰）是一名杀手，今天是他的生日，他答应妻子会在家和她一起准备晚餐。此时，施耐德接到了上司梅尔滕斯（吉恩·伯沃依兹 Gene Bervoets 饰）打来的电话，梅尔滕斯委托施耐德去杀一个名叫巴克斯（亚历斯·冯·华麦丹 Alex van Warmerdam 饰）的男人，对于经验丰富的施耐德来说，这是一份十分轻松的工作，如果时间来得及的话，他完成任务后甚至能够赶回家吃午餐。巴克斯住在芦苇丛环绕的湖边小屋之中，每天依靠酒精和毒品自我麻痹，这一天和往常一样，他在昏昏沉沉中醒来，向其女儿弗兰西斯卡（玛丽亚·卡拉克曼 Maria Kraakman 饰）回来拜访，虽然巴克斯和女儿之间的关系向来不能算好，但他实际上十分期待此次会面，此时巴克斯并不知道的是，除了弗兰西斯卡外，今天还会有另一位不速之客。